منابع مشابه
TIM-3 as a molecular switch for tumor escape from innate immunity
Stimulation of immunity toward tumors has always been one of the most objectives of oncoimmunologists. The identification and characterization of key molecules that may potentially help immunity to contrast cancer progression is increasing over time. Among these factors, TIM-3 is wellrecognized to have multiple key roles in eliciting immunity toward pathogens. This transmembrane protein was ide...
متن کاملIntralesional Rose Bengal in melanoma elicits tumor immunity via HMGB1
Intralesional (IL) therapy is under investigation to treat dermal and subcutaneous metastatic cancer. Rose Bengal (RB) is a staining agent that was originally used by ophthalmologists and in liver function studies. Previously, IL injection of RB induced regression of injected and uninjected tumors in murine models. However, the relevant mechanism is yet unknown. In this study, we used an OVA-ex...
متن کاملTargeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
The immune response plays an important role in staving off cancer; however, mechanisms of immunosuppression hinder productive anti-tumor immunity. T cell dysfunction or exhaustion in tumor-bearing hosts is one such mechanism. PD-1 has been identified as a marker of exhausted T cells in chronic disease states, and blockade of PD-1-PD-1L interactions has been shown to partially restore T cell fun...
متن کاملCorrection: Tim-3 Expression in Cervical Cancer Promotes Tumor Metastasis
BACKGROUND T cell immunoglobulin mucin-3 (Tim-3) has been identified as a negative regulator of anti-tumor immunity. Recent studies highlight the important role of Tim-3 in the CD8(+) T cell exhaustion that takes place in both human and animal cancer models. However, the nature of Tim-3 expression in the tumor cell and the mechanism by which it inhibits anti-tumor immunity are unclear. This pre...
متن کاملPreparation and characterization of a novel nanobody against T-cell immunoglobulin and mucin-3 (TIM-3)
Objective(s): As T-cell immunoglobulin and mucin domain 3 (TIM-3) is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition. Based on the unique features of nanobodies, we aimed to construct an anti-TIM-3 nanobody as an appropriate tool for manipulating immune responses for future therapeutic purposes. Materials and Meth...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2012
ISSN: 1529-2908,1529-2916
DOI: 10.1038/ni.2396